师资队伍

首页  师资队伍  教师信息  生物化学与分子生物学系

张数鑫

发布时间:2022-12-29浏览次数:3553


 

博士，教授三级

招生专业：生物化学与分子生物学（博、硕士）；生物与医药（专业博、硕士）

联系方式：0538-8244008、sxzhang@sdau.edu.cn

个人简介

教授，博士生导师，第一批山东省泰山学者青年专家。以玉米、小麦和拟南芥为研究对象，围绕作物逆境表观遗传和盐碱地综合利用做了系统的研究，获得国际同行认可，主要研究成果对基因沉默机制进行了阐述，揭示了小RNA转录、加工和修饰降解的主要机制；系统鉴定了玉米籽粒萌发相关的小RNA和多个调控miRNA合成加工的新因子，为进一步解析基因沉默调控通路奠定基础；揭示了低温胁迫和开花过程中的表观遗传调控机制。以通讯或第一作者在PNAS、Nucleic Acids Research、Plant Physiology、Plant Journal等国际期刊上发表论文20余篇。生物化学与分子生物学国家级教学团队骨干，《分子生物学A》国家一流课程，排名第 2 位（2023）；《分子生物学B》校级一流课程，排名第 1 位（2022）。指导学生在国家级和省级创新创业竞赛中获奖多次，包括全国大学生生命科学竞赛山东赛区三等奖，山东省大学生生物学大赛二等奖，山东省大学生生化学大赛二等奖多次及优秀指导教师等。入选山东农业大学双一流建设“杰出青年人才计划”，兼任山东省植物生理与分子生物学学会常务理事，山东省生化学会理事等。主持山东省重点研发计划乡村振兴提振项目、山东省泰山学者人才工程项目、国家自然科学基金面上项目，山东省重点研发计划项目，山东省自然科学面上项目等9项。

教育工作经历

2003年，山东农业大学农学院，学士学位

2006年，山东农业大学农学院，作物遗传育种硕士学位，

2011年，中国科学院植物研究所/Leiden University联合培养，发育生物学博士

2011年10月至2015年4月在内布拉斯加州大学林肯分校生物学院，博士后\研究助理教授

2015年6月-今，山东农业大学生命科学学院，教授

教学工作

现任山东农业大学生物化学与分子生物学系主任、学科主任。承担本科生《分子生物学A》（英语双语）、《分子生物学B》、《基础生化实验》；研究生《高级生物化学与分子生物学》、《生命科学研究进展》、《农业生物技术研发与实践》等课程的年度教学工作。

研究方向

基因沉默的分子机制：以小麦、玉米为研究对象，揭示非编码RNA、组蛋白修饰、染色质重塑等表观遗传因素介导基因沉默和激活的分子机制。发掘调控生长发育和抗逆等过程的关键基因，建立基因表达的调控网络。

作物-环境互作的分子机理与新材料创制：开展小麦、玉米种质资源的耐逆性鉴定，利用现代生物学技术发掘耐逆关键候选位点/基因，开发功能标记，解析耐逆遗传基础；利用基因编辑、基因聚合等手段创制新种质。

科研项目

1.  山东省重点研发计划乡村振兴提振项目，盐碱地玉米/苜蓿复合种植及高值化综合利用技术研究与示范，204/11-2027/10、主持；

2. 山东省泰山学者青年专家，植物发育的表观遗传调控，2017/01-2021/12、主持；

3. 国家自然科学基金面上项目, 腈类特异蛋白NSP2调控拟南芥miRNA合成的分子机制研究，2020/01-2023/12、主持；

4. 山东农业大学人才引进启动资金，表观遗传调控，2015/06-2020/06、主持；

5. 山东省自然科学基金面上项目，玉米种子萌发过程中赤霉素信号相关小RNA的鉴定与功能分析，2017/08-2020/06、主持；

6. 山东省重点研发计划，玉米籽粒脱水速率与萌发吸胀的相关性及快速脱水种质材料的筛选与创制，2018/01-2019/12、主持；

7. 遗传工程国家重点实验室开放课题，PRL1突变体抑制子调控小RNA合成代谢的分子机理，2018/07-2020/12、主持；

8. 省部共建作物逆境适应与改良国家重点实验室开放课题，玉米脂质转移蛋白LTP抗旱机理研究，2020/01-2022/12、主持；

发表论文

  1. Xin, Xin; Li, Jinlong; Wang, Shu; Pan, Yunjiao; Ye, Linhan; Ma, Huiru; Zhang, Jiedao; Li, Xiang; Yang, Wei; Zhang Shuxin*.Cell Division Cycle 5 is important for exerting the repressive function of non-coding RNAs and PRC2 on FLC during vernalization. The Plant Journal. 2025.

  2. Wang Shu, Xin Xin, Zhang Jiedao, Li Xiang, Yang Wei, Zhang Shuxin*. Plant-Specific BLISTER Modulates miRNA Biogenesis by Regulating MIR transcription, HYL1 Phosphorylation and Nuclear Transport in Arabidopsis.Nucleic Acids Research.2025, 53 , gkaf1012

  3. Feng Qiuling, Li Qianjin, Chen Xinyu, Wu Hanyi, Chen Yixun, Jiang Shaolong, Yang, Wei*, Zhang, Shuxin*. The ZAT17-PRL1 module engages in the miRNA synthesis in Arabidopsis. Plant Physiol Biochem. 2025, doi: 10.1016/j.plaphy.2025.110077.

  4. Xin X, Ye L, Zhai T, Wang S, Pan Y, Qu K, Gu M, Wang Y, Zhang J, Li X, Yang W, Zhang, Shuxin*. CELL DIVISION CYCLE 5 controls floral transition by regulating flowering gene transcription and splicing in Arabidopsis. Plant Physiol. 2024, 23;197(1):kiae616. doi: 10.1093/plphys/kiae616.

  5. Xin, Xin, Wang, Shu, Pan, Yunjiao, Ye, Linhan, Zhai, Tingting, Gu, Mengjie, Wang, Yanjiao, Zhang, Jiedao, Li, Xiang, Yang, Wei*, Zhang, Shuxin*.MYB Transcription Factor CDC5 Activates CBF3 Expression to Positively Regulates Freezing Tolerance via Cooperating With ICE1 and Histone Modification in Arabidopsis. PLANT CELL AND ENVIRONMENT. 2024,10.1111/pce.15144

  6. Zhai, Tingting#; Teng, Jun#; Gu, Mengjie; Wang, Yanjiao; Qu, Ke; Yang, Wei*; Zhang, Shuxin*. Genome-wide identification and expression analysis of the Nitrile-specifier proteins (NSPs) in Brassica napus. CURRENT PLANT BIOLOGY, 2024, https://doi.org/10.1016/j.cpb.2024.100342

  7. He, Shidong; Wang, Hui; Lv, Minghao; Li, Shun; Song, Junhui; Wang, Rongxin; Jiang, Shaolong; Jiang, Lijun; Zhang, Shuxin* ; Li, Xiang*.Nanopore Direct RNA Sequencing Reveals the Short-Term Salt Stress Response in Maize Roots. Plants, 2024, 13, 405. https://doi.org/10.3390/plants13030405

  8. Tingting Zhai, Jun Teng, Xintong Fan, Shaowei Yu, Chen Wang, Xingqi Guo, Wei Yang* and Shuxin Zhang*. Nitrile-Specific Protein NSP2 and Its Interacting ProteinMPK3 Synergistically Regulate Plant Disease Resistance in Arabidopsis. Plants, 2023, 12, 2857. https://doi.org/10.3390/plants12152857

  9. Wei-Bo Xu, Lei Zhao, Peng Liu, Qian-Huan Guo, Chang-Ai Wu, Guo-Dong Yang,Jin-Guang Huang, Shu-Xin Zhang, Xing-Qi Guo, Shi-Zhong Zhang, Cheng-Chao Zheng and Kang Yan. Intronic microRNA-directed regulation of mitochondrial reactive oxygen species enhances plant stress tolerance in Arabidopsis. New Phytologist, 2023, 240: 710–726 doi: 10.1111/nph.19168

  10. Qiuling Feng, Luming Zhao, Shaolong Jiang, Yanxin Qiu, Tingting Zhai, Shaowei Yu, Wei Yang*, Shuxin Zhang*.  The C2H2 family protein ZAT17 engages in the cadmium stress response by interacting with PRL1 in Arabidopsis. Journal of Hazardous Materials, 2024, 465(2024)133528

  11. Wei Yang#, Xiao Liu#, Shaowei Yu#, Jisheng Liu, Lijun Jiang, Xiaoduo Lu, Yinggao Liu, Jiedao Zhang, Xiang Li*, Shuxin Zhang*.The maize ATP binding cassette (ABC) transporter ZmMRPA6 confers cold and salt stress tolerance in plants. Plant Cell Reports, 2024, 43:13

  12. Liu J#, Guo X#, Zhai T, Shu A, Zhao L, Liu Z*, Zhang S*. Genome-wide identification and characterization of microRNAs responding to ABA and GA in maize embryos during seed germination.Plant Biol.,  2020, doi: 10.1111/plb.13142.

  13. Zhang S*, Dou Y, Li S, Ren G, Chevalier D, Zhang C, Yu B*.  DAWDLE Interacts with DICER-LIKE Proteins to Mediate Small RNA Biogenesis.Plant Physiol., 2018, 177(3):1142-1151.

  14. Zhang S, Liu Y*, Yu B*.  New insights into pri-miRNA processing and accumulation in plants. WIREs RNA, 2015, 6: 533-545.

  15. Wang X#, Zhang S#, Dou Y#, Zhang C, Chen X, Yu B*, Ren GD*. Synergistic and Independent Actions of Multiple Terminal Nucleotidyl Transferases in the 3' Tailing of Small RNAs in Arabidopsis. PLOS Genetics, 2015, 11(4): e1005091.

  16. Zhang S, Liu Y*, Yu B*.  PRL1, an RNA-binding protein, positively regulates the accumulation of miRNAs and siRNAs in Arabidopsis. PLOS Genetics, 2014, 10(12): e1004841.

  17. Xie M#,Zhang S# & Yu B*.   microRNA biogenesis, degradation and activity in plants.Cell Mol Life Sci.,  2014, DOI 10.1007/s00018-014-1728-7.

  18. Zhang S, Xie M, Ren G, Yu B*. CDC5, a DNA binding protein, positively regulates posttranscriptional processing and/or transcription of primary microRNA transcripts. Proc Natl Acad Sci USA., 2013,110: 17588-17593.

  19. Zhang S, Haider I, Kohlen W, Jiang L, Bouwmeester H, Meijer AH, Schluepmann H, Liu C*, Ouwerkerk PB*. Function of the HD-Zip I gene Oshox22 in ABA-mediated drought and salt tolerances in rice. Plant Mol Biol., 2012, 6, 571-585.

  20. Wang C#, Guo H#, He X, Zhang S, Wang J, Wang L, Guo D, Guo X. Scaffold protein GhMORG1 enhances the resistance of cotton to Fusarium oxysporum by facilitating the MKK6-MPK4 cascade.Plant Biotechnol J.,  2020, 18(6):1421-1433.

  21. Wang J, Wang L, Yan Y, Zhang S, Li H, Gao Z, Wang C*, Guo X*.  GhWRKY21 regulates ABA-mediated drought tolerance by fine-tuning the expression of GhHAB in cotton. Plant Cell Rep.,  2020, doi: 10.1007/s00299-020-02590-4.

  22. Li S, Li M, Liu K, Zhang H, Zhang S, Zhang C, Yu B*. MAC5, an RNA-binding protein, protects pri-miRNAs from SERRATE-dependent exoribonuclease activities. Proc Natl Acad Sci USA., 2020,  117(38):23982-23990.

  23. Li S, Liu K,  Zhou B, Li M, Zhang S, Zeng L, Zhang C, Yu B*. MAC3A and MAC3B, Two Core Subunits of the MOS4-Associated Complex, Positively Influence miRNA Biogenesis.  Plant Cell. 2018, 30: 481-494.

  24. Li S , Liu K, Wang X, Zhang S, Rogers  K, Ren G, Zhang C, Yu B* .STV1, a ribosomal protein, binds primary microRNA transcripts to promote their interaction with the processing complex in Arabidopsis. Proc Natl Acad Sci USA., 2017,114(6): 1424-1429.

  25. Wang C, He X, Wang X,Zhang S, Guo X*.  ghr-miR5272a-mediated regulation of GhMKK6 gene transcription contributes to the immune response in cotton. J Exp Bot., 2017, 16; 68(21-22):5895-5906.

  26. Feng B, Ma S, Chen S, Zhu N, Zhang S, Yu B, Yu Y, Le B, Chen X, Dinesh-Kumar S P, Shan L, He P*. PARylation of the forkhead-associated domain protein DAWDLE regulates plant immunity. EMBO Reports. 2016, 17(12): 1799-1813.

  27. Ren G, Xie M,Zhang S, Vinovskis C, Chen X*, Yu B*. Methylation protects microRNAs from an AGO1-associated activity that uridylates 5' RNA fragments generated by AGO1 cleavage. Proc Natl Acad Sci USA.,  2014,111, 6356-6370.

  28. Ren G, Xie M, Dou Y, Zhang S, Zhang C, Yu B*.  Regulation of miRNA abundance by RNA binding protein TOUGH in Arabidopsis. Proc Natl Acad Sci USA.,  2012, 109: 12817-12821.