隋森芳

隋森芳

博士

教授，博士生导师

中国科学院院士

电话：+86-10-62792083/62784768

邮箱: suisf@mail.tsinghua.edu.cn

简历

1964-1970清华大学精密仪器系，学士

1978-1981清华大学工程物理系，硕士

1985-1988德国慕尼黑工业大学生物物理所，博士

1989-1991清华大学生物科学与技术系，副教授

1991.1-至今清华大学生命科学学院（2009年9月以前为生物科学与技术系），教授、博导

研究内容

我们利用冷冻电子显微学，结合生物化学、生物物理学和细胞生物学等技术手段，研究：
（1）蛋白质复合体、复杂蛋白质机器和膜蛋白的结构、功能与工作机制；
（2）囊泡运输中的分子机制，蛋白质与膜脂的相互作用，生物膜与重大疾病的关系。

代表性论文

1. Liu ZF*, You X, Li M, Sui SF*. (2026) Structures of Photosynthetic Supramolecular Complexes. Annu Rev Biophys., doi: 10.1146/annurev-biophys-021424-011156. Online ahead of print.

2. Ma JF*, You X, Sun S, Sui SF*. (2025) Light-induced structural adaptation of the bundle-shaped phycobilisome from thylakoid-lacking cyanobacterium Gloeobacter violaceus. Nat Commun., 16(1):5956.

3. Cheppali S, Li C, Xing WJ, Sun R, Yang M, Xue Y, Lu SY, Yao J, Sun S*, Chen CL*, Sui SF*. (2025) Single-molecule two- and three-colour FRET studies reveal a transition state in SNARE disassembly by NSF. Nat Commun., 16(1):250.

4. Su JY, Tian XY, Cheng H, Liu DS, Wang ZY, Sun S*, Wang HW*, Sui SF*. (2025) Structural insight into synergistic activation of human 3-methylcrotonyl-CoA carboxylase. Nat Struct Mol Biol., 32(1):73-85.

5. Zhang X, Xiao Y, You X, Sun S, Sui SF*. (2024) In situ structural determination of cyanobacterial phycobilisome-PSII supercomplex by STAgSPA strategy. Nat Commun., 15(1):7201.

6. Li ZQ, Chen S, Zhao L, Huang GQ, Xu H, Yang XY, Wang PY, Gao N, Sui SF*. (2023) Nuclear export of pre-60S particles through the nuclear pore complex. Nature, 618(7964):411-418.

7. You X, Zhang X, Cheng J, Xiao YN, Ma JF, Sun S, Zhang XZ*, Wang HW*, Sui SF*. (2023) In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex. Nature, 616(7955):199-206.

8. Li ZQ, Chen S, Zhao L, Huang GQ, Pi X, Sun S, Wang PY, Sui SF*. (2022) Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex. Cell Research, 32(5):437-450.

9. Mi CC, Zhang L, Huang GQ, Shao G, Yang F, You X, Dong MQ, Sun S*, Sui SF*. (2022) Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32. Science Advances, 8(4):eabi5603.

10. Sui SF*. (2021) Structure of Phycobilisomes. Annu Rev Biophys., 50:53-72. (Review)

11. Hu MQ, Yang F, Huang YW, You X, Liu D, Sun S*, Sui SF*. (2021) Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake.Science Advances, 7(29):eabg3188.

12. Ma J, You X, Sun S, Wang X, Qin S, Sui SF*. (2020) Structural basis of energy transfer in Porphyridium purpureum phycobilisome. Nature, 579(7797):146-151.

13. Pi X, Zhao S, Wang W, Liu D, Xu C, Han G, Kuang T*, Sui SF*, Shen JR*. (2019) The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex. Science, 365(6452):eaax4406.

14. Huang X, Sun S, Wang X, Fan F, Zhou Q, Lu S, Cao Y, Wang QW, Dong MQ, Yao J, Sui SF*. (2019) Mechanistic insights into the SNARE complex disassembly.Science Advances, 5(4):eaau8164.

15. Zhang J, Ma J, Liu D, Qin S, Sun S*, Zhao J, Sui SF*. (2017) Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551(7678):57-63.