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李厦
发布时间：2022-12-28 作者: 浏览次数:390


学历: 博士              所属部门: 生物技术系

职称: 教授          招生专业: 细胞生物学（博士、硕士）

联系电话: 0538-8246365          E-mail: shali@sdau.edu.cn

个人简介

李厦, 博士, 教授, 博士生导师, 2005年在德国科隆大学获得硕士学位; 2014年在山东农业大学获得发育生物学方向博士学位。2010起就就职于山东农业大学。目前主要从事细胞生物学的教学和科研工作，近几年主持和参加国家和省级科研基金10余项。在国际主流学术期刊Plant Cell, Plant Physiol, Plant Journal等刊物上发表SCI论文60余篇，影响因子超过200。

个人荣誉

1. 山东省自然科学奖 “植物雌雄配子体发育的调控机理”。（2020年，二等/2位）

2. 山东省研究生优秀成果奖 “剪切因子在拟南芥早期胚发育过程中的功能研究”。（2019年，一等/2位）

3. 山东省高等学校科学技术奖“适配蛋白复合体调控植物有性生殖的分子机理研究“。（2019年，三等/1位）

4. 山东省高等学校科学技术奖“棕榈酰转移酶10调控植物生长及逆境响应的分子机理研究”。 （2017年，二等/1位）

5. 山东省高等学校科学技术奖“花粉管导向生长的分子网络”。（2016年，二等/1位）

6. 山东高等学校优秀科研成果奖（自然科学类）“活性氧调控花药绒毡层程序性死亡的分子机制”。 （2015年，二等/2位）

教学工作

1.本科生«细胞生物学» 理论课和实验课

2.研究生«细胞生物学研究进展»

研究方向

1. 蛋白质棕榈酰化：作为一种可逆的蛋白翻译后修饰方式，棕榈酰化对于被修饰底物蛋白发挥功能起到重要的作用。发现和鉴定蛋白质棕榈酰化酶在植物生长发育及对环境响应过程中的作用。

2. 根毛的生长调控机制：主要探究小G蛋白ROP，激酶以及转录因子RSL4在根毛生长中的作用机理。

3. 植物抗旱：寻找新的抗旱基因（参与调控气孔开闭）并揭示其工作机制。

科研项目

1. 《拟南芥SNARE蛋白YKT61调控雌雄配子体发育的分子机理研究》国家自然科学基金面上项目, （2020-2023）主持

2.《拟南芥棕榈酰基转移酶（PAT1/2/3/4/8）调控花粉管接纳的功能和机理研究》国家自然科学基金面上项目, （2018-2021）主持

3.《囊泡运输介导的膜蛋白分拣调控胚珠发育的机理研究》, 山东自然科学基金英才项目（2014-2017）主持

4.《拟南芥液泡膜上棕榈酰转移酶运输途径及底物特异性解析》,国家博士后基金第九批特别资助（2016-2017）主持

5.《适配蛋白复合体AP1调控胚珠发育的机理研究》, 中国博士后科学基金（57批）（2015-2016）主持

6.《适配蛋白复合体1（AP1G）调控拟南芥雌雄配子体功能的分子机理研究》,

山东省2015年度省博士后创新项目专项资金（2015-2016）主持

7.《蛋白棕榈酰化对于根毛极性生长的调控机理》,植物分子遗传国家重点实验室开放课题（2015-2017）主持

8.《 植物传粉与受精的分子调控网络》,科技部973计划, 2013-2017参加

9.《生长素与黄酮类互作在调控拟南芥花粉管生长中的分子机制》，国家基金委重大研究计划--培育项目，2011-2013，参加

10.《生物钟关键基因TaTOC1调控小麦春化作用的分子机理》 国家自然科学基金，2012-2016，参加

11.《糖基磷脂酰肌醇锚定蛋白MDP在花粉管生长和导向过程中的作用机理研究》,国家自然科学基金面上项目，2013/01-2016/12、参加

12.《玉米花粉响应高温胁迫关键基因的分离和功能分析》山东省自然科学杰出青年基金, 2013-2015, 参加



13.《棕榈酰转移酶DHHC11调控植物生长发育的分子及细胞机理研究》国家自然科学基金-香港基金委合作项目，2013/01-2016/12, 参加

14.《活性氧调控花药绒毡层细胞程序性死亡的分子机理研究》国家自然科学基金面上项目, 2015-2018, 参加

发表论文

2022年

  1. Guang-Jiu Hao, Xin-Ying Zhao, Miao-Miao Zhang2, Jun Ying, Fei Yu, Sha Li and Yan Zhang*（2022）Vesicle trafficking in Arabidopsis pollen tubes.FEBS Letters 596 (2022) 2231–2242

2.  Zheng Qin, Ya-Nan Wu, Tian-Tian Sun, Ting Ma, Meng Xu, Chen Pang, Shan-Wei Li*and Sha Li*（2022）Arabidopsis RAN GTPases are critical for mitosis during male and female gametogenesis.FEBS Letters (2022)

3.  En Li*, Yu-Ling Zhang, Zheng Qin, Meng Xu, Qian Qiao, Sha Li, Shan-Wei Li, Yan Zhang*（2022）Signaling network controlling ROP-mediated tip growth in Arabidopsis and beyond. Plant Communications https://doi.org/10.1016/j.xplc.2022.100451

2021年

  1. Rui-Min Zhu, Min Li, Shan-Wei Li, Xin Liang, Sha Li, Yan Zhang* (2021) Arabidopsis ADP-RIBOSYLATION FACTOR-A1s mediate tapetum-controlled pollen development. Plant J 108, 268-280

  2. Ting Ma, En Li, Lu-Shen Li, Sha Li, Yan Zhang*(2021) The Arabidopsis R-SNARE protein YKT61 is essential for gametophyte development. J Integr Plant Biol 63: 676-694.

  3. En Li, Yu-Ling Zhang, Xuelian Shi, Han Li, Xuefeng Yuan, Sha Li*, Yan Zhang* (2021) A positive feedback circuit for ROP-mediated polar growth. Mol Plant 14, 395-410

  4. Fei Liu, Ji-Peng Li, Lu-Shen Li, Qi Liu, Shan-Wei Li, Ming-Lei Song, Sha Li*, Yan Zhang* (2021) The canonical α-SNAP is essential for gametophytic development in Arabidopsis. PLoS Genet 17: e1009505

  5. Lu-Shen Li, Jun Ying, En Li, Ting Ma, Min Li, Li-Min Gong, Guo Wei, Yan Zhang, Sha Li* (2021) Arabidopsis CBP60b is a central transcriptional activator of immunity. Plant Physiol. 186, 1645-1659

  6. Feng Xiong, Edwin P. Groot, Yan Zhang, Sha Li* (2021) Functions of plant importin β proteins beyond nucleocytoplasmic transport. J Exp Bot. 72, 6140-6149

2020年

  1. Feng Xiong#, Cun-Ying Duan#, Hai-Hong Liu, Ju-Hua Wu, Zhong-Hui Zhang, Sha Li*, Yan Zhang* (2020) Arabidopsis KETCH1 is critical for the nuclear accumulation of ribosomal proteins and gametogenesis. Plant Cell 32, 1270-1284

  2. Xin Liang#, Shan-Wei Li#, Li-Min Gong, Sha Li,Yan Zhang* (2020) Arabidopsis Sar1b and Sar1c play distinct yet interchangeable roles in pollen development. Plant Physiol 183, 974-985

  3. Fu-Rong Ge, Sen Chai, Sha Li, Yan Zhang* (2020) Targeting and signaling of Rho of plants guanosine triphosphatases require synergistic interaction between GDI and vesicular trafficking. J Integr Plant Biol. 62, 1484-1499

  4. Feng Xiong, Bi-Ke Zhang, Hai-Hong Liu, Guo Wei, Ju-Hua Wu, Ya-Nan Wu,Yan Zhang*, Sha Li* (2021) Transcriptional regulation of PLETHORA1 in root meristem through an importin and its two antagonistic cargos. Plant Cell 32, 3812-3824

  5. En Li, Guangda Wang, Yu-Ling Zhang, Zhaosheng Kong, Sha Li* (2020) FERONIA mediates root nutating growth. Plant J 104, 1105-1116

  6. Sen Chai, Fu-Rong Ge, Yan Zhang, Sha Li* (2020) S-acylation of CBL10/SCaBP8 by PAT10 is crucial for its tonoplast association and function in salt tolerance. J Integr Plant Biol 62, 718-722

  7. Shuai-Jie Wei#, Sen Chai#, Rui-Min Zhu, Cun-Ying Duan, Yan Zhang, and Sha Li* (2020) HUA ENHANCER1 mediates ovule development. Front. Plant Sci. 11:397

  8. Sen Chai#, En Li#, Yan Zhang, Sha Li* (2020) NRT1.1-mediated nitrate suppression of root coiling relies on PIN2- and AUX1-mediated auxin transport. Front. Plant Sci. 11, 671

  9. Rui-Min Zhu, Sen Chai, Zhuang-Zhuang Zhang, Chang-Le Ma,Yan Zhang, Sha Li* (2020) Arabidopsis Chloroplast protein for Growth and Fertility1 (CGF1) and CGF2 are essential for chloroplast development and female gametogenesis. BMC Plant Biol 20, 172

  10. Feng Xiong* and Sha Li* (2020) SF3b4: a versatile player in eukaryotic cells. Frontiers Cell Dev Biol. 8:14

  11. Sen Chai , Yongxin Nie & Sha Li* (2020) Nitrate deficiency induces differential endocytosis in roots through NRT1.1, Plant Signaling & Behavior, DOI:10.1080/15592324.2020.179439

12. Feng Xiong & Sha Li* (2020) Spliceosome component JANUS fulfills a role of mediator in transcriptional regulation during Arabidopsis development, Plant Signaling & Behavior, DOI: 10.1080/15592324.2020.1841974

13. Wang Z-Q, Liu Q, Wu J-H, Li J,He J-M, Zhang Y and Sha Li* (2020) Downregulating VAC14 in Guard Cells Causes Drought Hypersensitivity by Inhibiting Stomatal Closure. Front. Plant Sci. 11:602701.


2019年

  1. Hai-Hong Liu, Feng Xiong, Cun-Ying Duan, Ya-Nan Wu, Yan Zhang, Sha Li* (2019) IMPORTIN β4 mediates nuclear import of GRF-INTERACTING FACTORs to control ovule development in Arabidopsis. Plant Physiol 179, 1080-1092

  2. Feng Xiong, Hai-Hong Liu, Cun-Ying Duan, Bi-Ke Zhang, Guo Wei, Yan Zhang, Sha Li* (2019) Arabidopsis JANUS regulates embryonic pattern formation through Pol II-mediated transcription of WOX2 and PIN7. iScience 19, 1179-1188


2018年

  1. En Li, Yong Cui, Fu-Rong Ge, Sen Chai, Wei-Tong Zhang, Qiang-Nan Feng, Liwen Jiang, Sha Li*, Yan Zhang*(2018) AGC1.5 kinase phosphorylates RopGEFs to control pollen tube growth. Mol Plant 11, 1198-1209

  2. Qiang-Nan Feng, Xin Liang, Sha Li, Yan Zhang* (2018) AP-3 mediates pollen tube growth by coordinating vacuolar targeting and organization. Plant Physiol. 177, 216-225.

  3. Wei-Tong Zhang#, En Li#, Yan-Kui Guo, Shi-Xia Yu, Zhi-Yuan Wan, Ting Ma, Sha Li, Tomoko Hirano, Masa H. Sato, Yan Zhang* (2018) Arabidopsis VAC14 is critical for pollen development through mediating vacuolar organization. Plant Physiol 177, 1529-1538

  4. Shi-Jian Song, Qiang-Nan Feng, Chun-Long Li, En Li, Qi Liu, Hui Kang, Wei Zhang, Yan Zhang, Sha Li* (2018) A tonoplast-associated calcium-signaling module dampens ABA signaling during stomatal movement. Plant Physiol 177, 1666-1678

  5. Xin Liang, Qiang-Nan Feng, Sha Li, Yan Zhang* (2018) Vacuolar trafficking in pollen tube growth and guidance. Plant Signal Behav DOI:10.1080/15592324.2018.1464854

2017年

  1. Jia-Gang Wang, Chong Feng, Hai-Hong Liu, Qiang-Nan Feng, Sha Li, Yan Zhang* (2017) AP1G mediates vacuolar acidification during synergid-controlled pollen tube reception. Proc Nat Acad Sci. U.S.A. 114, E4877-E4883

  2. Qiang-Nan Feng, Shi-Jian Song, Shi-Xia Yu, Jia-Gang Wang, Sha Li, Yan Zhang (2017) AP-3-dependent vacuolar trafficking of Arabidopsis PAT10 involves a subpopulation of COPII and the vacuolar tethering complex HOPS. Plant Physiol 174, 1609-1620

  3. Shi-Xia Yu, Qaing-Nan Feng, Hong-Tao Xie, Sha Li, Yan Zhang* (2017) Reactive oxygen species mediate tapetal programmed cell death in tobacco and tomato. BMC Plant Biol 17, 76

  4. Chong Feng1, Jia-Gang Wang1, Hai-Hong Liu, Sha Li*, Yan Zhang* (2017) Arabidopsis adaptor protein 1G is critical for pollen development. J Integr Plant Biol 59, 594-599

  5. Zhi-Yuan Wan, Sen Chai, Fu-Rong Ge, Qiang-Nan Feng, Yan Zhang, Sha Li* (2017) Arabidopsis PROTEIN S-ACYL TRANSFERASE4 mediates root hair growth. Plant J 90, 249-260

  6. Qiang-Nan Feng, Yan Zhang, Sha Li* (2017) Tonoplast targeting of VHA-a3 relies on a Rab5-mediated but Rab7-independent vacuolar trafficking route. J Integr Plant Biol 59, 230-233


2016年之前

  1. Jia-Gang Wang, Chong Feng, Hai-Hong Liu, Fu-Rong Ge, Sha Li, Hong-Ju Li, Yan Zhang* (2016) HAPLESS13-mediated trafficking of STRUBBELIG is critical for ovule development in Arabidopsis. Plos Genet 12 (8)

  2. Sen Chai#, Fu-Rong Ge#, Qiang-Nan Feng, Sha Li, Yan Zhang* (2016) PLURIPETALA mediates ROP2 localization and stability in parallel to SCN1 but synergistically with TIP1 in root hairs. Plant J, 86, 413-426  

  3. Qiang-Nan Feng, Hui Kang, Shi-Jian Song, Fu-Rong Ge, Yu-Ling Zhang, En Li, Sha Li, Yan Zhang*(2016) Arabidopsis RhoGDIs are critical for cellular homeostasis of pollen tubes. Plant Physiol 170, 841-856

  4. Xin-Ying Zhao#, Jia-Gang Wang#, Shi-Jian Song, Qun Wang, Hui Kang, Yan Zhang*, Sha Li* (2016) Precocious leaf senescence by functional loss of PROTEIN S-ACYLTRANSFERASE14 involves the NPR1-dependent salicylic acid signaling. Sci Rep. 6, 20309

  5. Sen Chai, Furong Ge, Sha Li, Yan Zhang* (2016) The journey to glory: receptor-like kinases in pollen tube growth. Sci Bull 61, 827-831

  6. Sha Li, Yan Zhang* (2016) GPI in pollen tubes: Found! Sci China Life Sci DOI: 10.1007/s11427-016-5032-7

  7. Yu-Ling Zhang, En Li, Qiang-Nan Feng, Xin-Ying Zhao, Fu-Rong Ge, Yan Zhang, Sha Li* (2015) Protein palmitoylation is critical for the polar growth of root hairs in Arabidopsis. BMC Plant Biol 15;50

  8. Hong-Tao Xie, Zhi-Yuan Wan, Sha Li, Yan Zhang* (2014) Spatiotemporal production of reactive oxygen species by NADPH oxidase is critical for tapetal programmed cell death and pollen development in Arabidopsis. Plant Cell 27, 2007-2023

  9. Sha Li, Yan Zhang* (2014) To grow or not to grow. FERONIA has her say. Mol Plant 7, 1261-1263

  10. Liang-Zi Zhou#, Sha Li#, Qiang-Nan Feng, Yu-Ling Zhang, Xinying Zhao, Yonglun Zeng, Hao Wang, Liwen Jiang, Yan Zhang* (2013) PROTEIN S-ACYL TRANSFERASE10 is critical for development and salt tolerance in Arabidopsis. Plant Cell 25, 1093-1107

  11. Sha Li#, Fu-Rong Ge#, Ming Xu#, Xin-Ying Zhao, Guo-Qiang Huang, Liang-Zi Zhou, Jia-Gang Wang, Anja Kombrink, Sheila McCormick, Xian Sheng Zhang*, Yan Zhang* (2013) Arabidopsis COBRA-LIKE 10, a GPI-anchored protein, mediates directional growth of pollen tubes. Plant J 74, 486-497

  12. Jia-Gang Wang#, Sha Li#, Xin-Ying Zhao, Liang-Zi Zhou, Guo-Qiang Huang, Chong Feng, Yan Zhang* (2013) HAPLESS13, the Arabidopsis µ1 adaptin, is essential for protein sorting at the trans-Golgi network/early endosome. Plant Physiol 162, 1897-1910

  13. Guo-Qiang Huang#, En Li#, Fu-Rong Ge, Sha Li, Qun Wang, Chun-Qing Zhang, Yan Zhang* (2013) Arabidopsis RopGEF4 and RopGEF10 are important for FERONIA-mediated developmental but not environmental regulation of root hair growth. New Phytol 200, 1089-1101

  14. Sha Li#, Liang-Zi Zhou#, Qiang-Nan Feng, Sheila McCormick, Yan Zhang* (2013) The C-terminal hypervariable domain targets Arabidopsis ROP9 to the invaginated pollen tube plasma membrane. Mol Plant 6, 1362-1364

  15. Xin-Ying Zhao#, Qun Wang#, Sha Li#, Fu-Rong Ge, Liang-Zi Zhou, Sheila McCormick, Yan Zhang* (2013) The Juxtamembrane and carboxy-terminal domains of Arabidopsis PRK2 are critical for ROP-induced growth in pollen tubes. J Exp Bot 64,5599-5610

16.Yan Zhang, Sha Li, Liang-Zi Zhou, Emily Fox, James Pao, Wei Sun, Chao Zhou ，Sheila McCormick (2011)Overexpression of Arabidopsis thaliana PTEN caused accumulation of autophagic bodies in pollen tubes by disrupting phosphatidylinositol 3-phosphate dynamics. Plant J(2011) 68, 1081–1092


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