Thomas Laux

学历：博士

所属部门：植物学系

职称：教授

招生专业：发育生物学（博士、硕士）

联系电话：0538-8242127

Email：lzzhou@sdau.edu.cn

个人简介：

Thomas Laux，博士，教授，博士生导师，“长江学者奖励计划”讲席学者，德国弗莱堡大学生物学院和高等研究院教授（W3 Professor）。Thomas Laux教授长期致力于植物干细胞命运决定和植物早期胚胎发生的分子机理研究。他作为项目负责人主持多项德国科学基金会（DFG）重大专项及德国重点研发计划。相关研究工作发表于Cell (3篇)、Nature (1篇)、Science (1篇)、Genes & Development (2篇)、Developmental Cell (5篇)、Current Biology (4篇)和The Plant Cell (6篇)等国际顶尖学术杂志，并多次应邀为Cell、Trends in plant science、The Plant Cell、Current Biology、EMBO Journal、Annual Review of Plant Biology和Current Opinion in Plant Biology等国际著名期刊撰写综述。Thomas Laux教授于2008-2016年获邀担任Cell Stem Cell编委。因其在植物发育生物学领域的杰出贡献，他于2002年和2009年先后荣获法国科学院August Chevalier研究奖和德国遗传与发育生物学学会Cornelia Harte奖项，并于2010年当选欧洲分子生物学学会会士(EMBO member)。此外，Thomas Laux教授具有丰富的教学及学生指导经验，长期负责德国-法国-瑞士联合生物技术专业、欧洲植物胚胎高级研讨会等课程的组织及主持工作。目前实验室培养的学生中，已有超过20位研究者成为了世界各大知名高校的教授。

获得奖励：

2010年 欧洲分子生物学学会会士(EMBO member)

2009年 德国遗传与发育生物学学会Cornelia Harte奖

2002年 法国科学院August Chevalier研究奖

教学工作：

参与讲授博士生课程“植物干细胞与发育”

研究方向：

植物干细胞命运决定和植物早期胚胎发生的分子机理研究

代表性论文：

Laux, T. (2003). The stem cell concept in plants: a matter of debate. Cell 113, 281-283.

Lenhard, M., Bohnert, A., Jurgens, G., and Laux, T. (2001). Termination of stem cell maintenance in Arabidopsis floral meristems by interactions between WUSCHEL and AGAMOUS. Cell 105, 805-814.

Schoof, H., Lenhard, M., Haecker, A., Mayer, K.F., Jurgens, G., and Laux, T. (2000). The stem cell population of Arabidopsis shoot meristems in maintained by a regulatory loop between the CLAVATA and WUSCHEL genes. Cell 100, 635-644.

Mayer, K.F., Schoof, H., Haecker, A., Lenhard, M., Jurgens, G., and Laux, T. (1998). Role of WUSCHEL in regulating stem cell fate in the Arabidopsis shoot meristem. Cell 95, 805-815.

Sarkar, A.K., Luijten, M., Miyashima, S., Lenhard, M., Hashimoto, T., Nakajima, K., Scheres, B., Heidstra, R., and Laux, T. (2007). Conserved factors regulate signalling in Arabidopsis thaliana shoot and root stem cell organizers. Nature 446, 811-814.

Robert, H.S., Park, C., Gutierrez, C.L., Wojcikowska, B., Pencik, A., Novak, O., Chen, J., Grunewald, W., Dresselhaus, T., Friml, J., and Laux, T. (2018). Maternal auxin supply contributes to early embryo patterning in Arabidopsis. Nat Plants 4, 548-553.

Aichinger, E., Kornet, N., Friedrich, T., and Laux, T. (2012). Plant stem cell niches. Annu Rev Plant Biol 63, 615-636.

Lieber, D., Lora, J., Schrempp, S., Lenhard, M., and Laux, T. (2011). Arabidopsis WIH1 and WIH2 genes act in the transition from somatic to reproductive cell fate. Curr Biol 21, 1009-1017.

Zhang, Z., Tucker, E., Hermann, M., and Laux, T. (2017). A Molecular Framework for the Embryonic Initiation of Shoot Meristem Stem Cells. Dev Cell 40, 264-277 e264.

Pi, L., Aichinger, E., van der Graaff, E., Llavata-Peris, C.I., Weijers, D., Hennig, L., Groot, E., and Laux, T. (2015). Organizer-Derived WOX5 Signal Maintains Root Columella Stem Cells through Chromatin-Mediated Repression of CDF4 Expression. Dev Cell 33, 576-588.

Knauer, S., Holt, A.L., Rubio-Somoza, I., Tucker, E.J., Hinze, A., Pisch, M., Javelle, M., Timmermans, M.C., Tucker, M.R., and Laux, T. (2013). A protodermal miR394 signal defines a region of stem cell competence in the Arabidopsis shoot meristem. Dev Cell 24, 125-132.

Ueda, M., Zhang, Z., and Laux, T. (2011). Transcriptional activation of Arabidopsis axis patterning genes WOX8/9 links zygote polarity to embryo development. Dev Cell 20, 264-270.

Breuninger, H., Rikirsch, E., Hermann, M., Ueda, M., and Laux, T. (2008). Differential expression of WOX genes mediates apical-basal axis formation in the Arabidopsis embryo. Dev Cell 14, 867-876.

Graf, P., Dolzblasz, A., Wurschum, T., Lenhard, M., Pfreundt, U., and Laux, T. (2010). MGOUN1 encodes an Arabidopsis type IB DNA topoisomerase required in stem cell regulation and to maintain developmentally regulated gene silencing. Plant Cell 22, 716-728.

Wurschum, T., Gross-Hardt, R., and Laux, T. (2006). APETALA2 regulates the stem cell niche in the Arabidopsis shoot meristem. Plant Cell 18, 295-307.

Baurle, I., and Laux, T. (2005). Regulation of WUSCHEL transcription in the stem cell niche of the Arabidopsis shoot meristem. Plant Cell 17, 2271-2280.

Du, F., Gong, W., Bosca, S., Tucker, M., Vaucheret, H., and Laux, T. (2020). Dose-Dependent AGO1-Mediated Inhibition of the miRNA165/166 Pathway Modulates Stem Cell Maintenance in Arabidopsis Shoot Apical Meristem. Plant Commun 1, 100002.

Lu, L., Holt, A., Chen, X., Liu, Y., Knauer, S., Tucker, E.J., Sarkar, A.K., Hao, Z., Roodbarkelari, F., Shi, J., Chen, J., and Laux, T. (2023). miR394 enhances WUSCHEL-induced somatic embryogenesis in Arabidopsis thaliana. New Phytol 238, 1059-1072.

Ueda, M., Aichinger, E., Gong, W., Groot, E., Verstraeten, I., Vu, L.D., De Smet, I., Higashiyama, T., Umeda, M., and Laux, T. (2017). Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote. Genes Dev 31, 617-627.

Gross-Hardt, R., Lenhard, M., and Laux, T. (2002). WUSCHEL signaling functions in interregional communication during Arabidopsis ovule development. Genes Dev 16, 1129-1138.