Xiaoyun Wang
发布时间： 2018-06-04                 浏览次数： 36


Xiaoyun Wang, Ph.D., Professor, xyunwang@sdau.edu.cn, 86-538-8242922

Research Interests:

Molecular biology of plant resistance to stresses, Molecular Enzymology

Education:

1979-1983 Shandong Agricultural University, BSc of Soil and Agricultural Chemistry

1987-1990 Shandong Agricultural University, MSc of Plant Physiology and Biochemistry

1994-1997 Shandong Agricultural University, PhD of Plant Physiology and Biochemistry

2002-2003 Visiting Scholar, Tsinghua University

2003-present Professor, Collage of Life Sciences, Shandong Agricultural University

2008-2010 Visiting Scholar, Harvard Medical School, Harvard University, US


Teaching Courses:

Biochemistry, Molecular biology, Protein structure and function

Selected Publications:

  1. Zhang Z, Yuan L, Liu X, Chen X.S, and Wang X.Y.*, Evolution analysis of Dof transcription factor family and their expression in response to multiple abiotic stresses in Malus domestica. Gene. 2018;639:137-48.

  2. Li M.C, Wei G.S, Shi W.C, Sun Z, Li H, Wang X.Y.*, and Gao Z*. Distinct distribution patterns of ammonia-oxidizing archaea and bacteria in sediment and water column of the Yellow River estuary. Scientific reports. 2018;8(1):1584.

  3. Wu QY, Zhu Y.Y, Wei F, Tong Y.X, Cao J, Zhou P,Li Y.Z,Zeng Y.L,Li F, Wang X.Y*,and Xu L.K*. et al. Mutation of the conserved G66 residue in GS region decreased structural stability and activity of arginine kinase. International journal of biological macromolecules. 2018;111:247-54.

  4. Liu X, Li R, Dai Y.Q, Chen X.S,and Wang X.Y.*, Genome-wide identification and expression analysis of the B-box gene family in the Apple (Malus domestica Borkh.) genome. Molecular genetics and genomics: MGG. 2017. DOI 10.1007/s00438-017-1386-1.

  5. Xu J.N, Xing S.S, Cui H.R, Chen X.S,and Wang X.Y*, Genome-wide identification and characterization of the apple (Malus domestica) HECT ubiquitin-protein ligase family and expression analysis of their responsiveness to abiotic stresses. Molecular genetics and genomics  2016;291(2):635-46.

  6. Xu J.N, Xing S.S, Zhang Z.R, Chen X.S,and Wang X.Y.*, Genome-Wide Identification and Expression Analysis of the Tubby-Like Protein Family in the Malus domestica Genome. Frontiers in plant science. 2016;7:1693.

  7. Yu Z.B, Yang X.J, Du J.J, Wan C.M, Xu J.N, Wang W.J, Xu J.N, Wang W.J, Feng Y.G, Wang X.Y*,  A homologue of vitamin K epoxide reductase in Solanum lycopersicum is involved in resistance to osmotic stress. Physiologia plantarum. 2016;156(3):311-22.

  8. Yang X. J., Cui H. R., Yu Z. B., Du J. J., Xu J. N., and Wang X. Y.*, Key Amino Acids of Arabidopsis VKOR in the Activity of Phylloquinone Reduction and Disulfide Bond Formation. Protein Pept Lett. 2015, 22:81-86.

  9. Lu Y., Peng J. J., Yu Z. B., Du J. J., Xu J. N., and Wang X. Y.*, Thylakoid membrane oxidoreductase LTO1/AtVKOR is involved in ABA-mediated response to osmotic stress in Arabidopsis. Physiol Plant. 2015, 154:28-38.

  10. Lu Y., Du J. J., Yu Z. B., Peng J. J., Xu J. N., and Wang X. Y.*, Identification of potential targets for thylakoid oxidoreductase AtVKOR/LTO1 in chloroplasts. Protein Pept Lett. 2015, 22:219-225.

  11. Li F., Li W., Liu Y., Tong Y. X., Zhou P., Wang L., Chen C., Zeng L. Y., Wu Q. Y. *, Wang X. Y. *, and Xu K. L. *, Effects of the I682F mutation on JAK2's activity, structure and stability. Int J Biol Macromol. 2015, 79:118-125.

  12. Du J. J., Zhan C. Y., Lu Y., Cui H. R., and Wang X. Y.*, The conservative cysteines in transmembrane domain of AtVKOR/LTO1 are critical for photosynthetic growth and photosystem II activity in Arabidopsis. Frontiers in Plant Science. 2015, 6:238.

  13. Cui H. R., Zhang Z. R., Lv W., Xu J. N., and Wang X. Y.*, Genome-wide characterization and analysis of F-box protein-encoding genes in the Malus domestica genome. Molecular Genetics and Genomics. 2015, 290:1-12.

  14. Jing X. L., Xu J., Fan M. N., Ma L., Huang X., Wang X. Y., Sun S. H., Zhu C. X., and Liu H. M., Mutation analysis of the RNA silencing suppressor NS1 encoded by avian influenza virus H9N2. Journal of General Virology. 2015, 96:1613-1618.

  15. Zhan C. Y., Xu J. N., Li D., Liu B. B., Feng Y. G., and Wang X. Y. *, Overexpression of AtCBF1 in Sinningia speciosa Enhances Chilling Stress Tolerance. Research & Reviews: Journal of Botanical Sciences. 2015, S1：26-33.

  16. Wu Q. Y., Guo H. Y., Geng H. L., Ru B. M., Cao J., Chen C., Zeng L. Y., Wang X. Y., Li F., and Xu K. L., T273 plays an important role in the activity and structural stability of arginine kinase. Int J Biol Macromol. 2014, 63:21-28.

  17. Wang P., Li X. Z., Cui H. R., Feng Y. G., and Wang X. Y*., Identification and functional analysis of a novel parvulin-type peptidyl-prolyl isomerase from Gossypium hirsutum. Plant Physiol Biochem. 2014, 76C:58-66.

  18. Wan C. M., Yang X. J., Du J. J., Lu Y., Yu Z. B., Feng Y. G., and Wang X. Y*., Identification and characterization of SlVKOR, a disulfide bond formation protein from Solanum lycopersicum, and bioinformatic analysis of plant VKORs. Biochemistry (Mosc). 2014, 79:440-449.

  19. Geng H. L., Bian M. R., Liu Y., Cao J., Chen C., Wang Z. Y., Li Z. Y., Zeng L. Y., Wang X. Y. *, Wu Q. Y. *, and Xu K. L. *, The D14 and R138 ion pair is involved in dimeric arginine kinase activity, structural stability and folding. Int J Biol Macromol. 2014, 66:302-310.

  20. Du F., Xu J. N., Zhan C. Y., Yu Z. B., and Wang X. Y.*, An obesity-like gene MdTLP7 from apple (Malus× domestica) enhances abiotic stress tolerance. Biochemical and biophysical research communications. 2014, 445:394-397.

  21. Du F., Xu J. N., Li D., and Wang X. Y.*, The identification of novel and differentially expressed apple-tree genes under low-temperature stress using high-throughput Illumina sequencing. Mol Biol Rep. 2014, 42:569-580.

  22. Yu Z. B., Lu Y., Du J. J., Peng J. J., and Wang X. Y.*, The chloroplast protein LTO1/AtVKOR is involved in the xanthophyll cycle and the acceleration of D1 protein degradation. J Photochem Photobiol B. 2013, 130C:68-75.

  23. Lu Y., Wang H. R., Li H., Cui H. R., Feng Y. G., and Wang X. Y*., A chloroplast membrane protein LTO1/AtVKOR involving in redox regulation and ROS homeostasis. Plant Cell Rep. 2013, 32:1427-1440.

  24. Li F., Wu Q. Y., and Wang X. Y., The amino acid residue L113 is involved in arginine kinase activity and structural stability. Int J Biol Macromol. 2013, 52:198-205.

  25. Wu Q. Y., Li F., Wang X. Y. *, and Xu K. L. *, Evidence that the amino acid residue Ile121 is involved in arginine kinase activity and structural stability. Int J Biol Macromol. 2012, 51:369-377.

  26. Wu Q. Y., Li F., Guo H. Y., Cao J., Chen C., Chen W., Zhao K., Zeng L. Y., Han Z. X., Li Z. Y., Wang X. Y. *, and Xu K. L. *, Amino acid residue E543 in JAK2 C618R is a potential therapeutic target for myeloproliferative disorders caused by JAK2 C618R mutation. Arch Biochem Biophys. 2012, 528:57-66.

  27. Wu Q. Y., Li F., Wang X. Y. *, and Chen Z. J. *, Impact of inter-subunit interactions on the dimeric arginine kinase activity and structural stability. Arch Biochem Biophys. 2011, 512:61-68.

  28. Wu Q. Y., Jin K. Z., Li F., Hu Z. Q., and Wang X. Y.*, Impact of intra-subunit interactions on the dimeric arginine kinase activity and structural stability. Int J Biol Macromol. 2011, 49:822-831.

  29. Wang X. Y., Dutton R. J., Beckwith J., and Boyd D., Membrane topology and mutational analysis of Mycobacterium tuberculosis VKOR, a protein involved in disulfide bond formation and a homologue of human vitamin K epoxide reductase. Antioxid Redox Signal. 2011, 14:1413-1420.

  30. Wang H. R., Zhu W. J., and Wang X. Y.*, Mechanism of inhibition of arginine kinase by flavonoids consistent with thermodynamics of docking simulation. Int J Biol Macromol. 2011, 49:985-991.

  31. Jing X. L., Fan M. N., Jia G., Liu L. W., Ma L., Zheng C. C., Zhu X. P., Liu H. M. *, and Wang X. Y.*, A Multifunctional Protein Encoded by Turkey Herpesvirus Suppresses RNA Silencing in Nicotiana benthamiana. J Virol. 2011, 85:12792-12803.

  32. Feng W. K., Wang L., Lu Y., and Wang X. Y.*, A protein oxidase catalysing disulfide bond formation is localized to the chloroplast thylakoids. FEBS J. 2011, 278:3419-3430.

  33. Li F., Wu Q. Y., Sun Y. L., Ma N. N., Wang X. Y., and Meng Q. W., Evidence that the amino acid residue Cys117 of chloroplastic monodehydroascorbate reductase is involved in its activity and structural stability. Int J Biol Macromol. 2010, 46:350-355.

  34. Wu X. Q., Zhu W. J., Lu Z. R., Xia Y., Yang J. M., Zou F., and Wang X. Y.*, The effect of rutin on arginine kinase: inhibition kinetics and thermodynamics merging with docking simulation. Int J Biol Macromol. 2009, 44:149-155.

  35. Wu X. Q., Xu H., Yue H., Liu K. Q., and Wang X. Y.*, Inhibition kinetics and the aggregation of alpha-glucosidase by different denaturants. Protein J. 2009, 28:448-456.

  36. Wu Q. Y., Li F., and Wang X. Y.*, Val65 plays an important role in the substrate synergism, structural stability and activity of arginine kinase. Int J Biol Macromol. 2009, 45:393-398.

  37. Shi X. W., Sun M. L., Zhou B., and Wang X. Y.*, Identification, characterization, and overexpression of a phytase with potential industrial interest. Can J Microbiol. 2009, 55:599-604.

  38. Zhou J. P., Yang Z. B., Yang W. R., Wang X. Y., Jiang S. Z., and Zhang G. G., Effects of a New Recombinant Phytase on the Performance and Mineral Utilization of Broilers Fed Phosphorus-Deficient Diets. The Journal of Applied Poultry Research. 2008, 17:331.

  39. Wu Q. Y., Li F., and Wang X. Y.*, Evidence that amino-acid residues are responsible for substrate synergism of locust arginine kinase. Insect Biochem Mol Biol. 2008, 38:59-65.

  40. Wu Q. Y., Li F., and Wang X. Y.*, Evidence that the amino acid residue P272 of arginine kinase is involved in its activity, structure and stability. Int J Biol Macromol. 2008, 43:367-372.

  41. Zhu W. J., Li M., and Wang X. Y.*, Chemical modification studies on arginine kinase: essential cysteine and arginine residues at the active site. Int J Biol Macromol. 2007, 41:564-571.

  42. Zhao D. M., Wang M., Mu X. J., Sun M. L., and Wang X. Y.*, Screening, cloning and overexpression of Aspergillus niger phytase (phyA) in Pichia pastoris with favourable characteristics. Lett Appl Microbiol. 2007, 45:522-528.

  43. Xia Y., Park Y. D., Mu H., Zhou H. M., Wang X. Y.*, and Meng F. G., The protective effects of osmolytes on arginine kinase unfolding and aggregation. Int J Biol Macromol. 2007, 40:437-443.

  44. Wu Q. Y., Li F., Zhu W. J., and Wang X. Y.*, Cloning, expression, purification, and characterization of arginine kinase from Locusta migratoria manilensis. Comp Biochem Physiol B Biochem Mol Biol. 2007, 148:355-362.