Le Jia, Professor, Ph.D, jiale@sdau.edu.cn
Research Interest:
Mushroom, Environmental microbiology
Education:
2010-2018 Professor, Collage of Life Sciences, Shandong Agricultural University
2003-2006 Collage of Life Sciences, Shandong Agricultural University, PhD
1993-1996 Collage of Life Sciences, Shandong Agricultural University, MSc
1985-1989 Collage of Life Sciences, Shandong University, BSc
Teaching Courses:
Microbiology, Mycology, Microbial Physiology, etc
Selected Publications:
1. Min Liu, Shangshang Li, XiuxiuWang, Yongfa Zhu, Jianjun Zhang, Hui Liu, Le Jia*. Characterization, anti-oxidation and anti-inflammation of polysaccharides by Hypsizygus marmoreus against LPS-induced toxicity on lung. International Journal of Biological Macromolecules. 2018, 111: 121–128.
2. Xiuxiu Wang, Min Liu, Chen Zhang, Shangshang Li, Qihang Yang, Jianjun Zhang, Zhiyuan Gong, Jiandong Han, Le Jia*. Antioxidant activity and protective effects of enzyme-extracted Oudemansiella radiata polysaccharides on alcohol-induced liver injury. Molecules. 2018, 23, 481. doi:10.3390/molecules23020481
3. Chen Zhang, Lan Zhang, Hui Liu, Jianjun Zhang, Chunlong Hu, Le Jia*. Antioxidation, anti-hyperglycaemia and renoprotective effects of extracellular polysaccharides from Pleurotus eryngii SI-04. International Journal of Biological Macromolecules. 2018, 111: 219–228.
4. Shangshang Li, Min Liu, Chen Zhang, Chengye Tian, Xiuxiu Wang, Xinling Song, Huijuan Jing, Zheng Gao, Zhenzhen Ren, Weiru Liu, Jianjun Zhang, Le Jia*. Purification, in vitro antioxidant and in vivo anti-aging activities of soluble polysaccharides by enzyme-assisted extraction from Agaricus bisporus. International Journal of Biological Macromolecules. 2018, 109: 457–466.
5. Huajie Zhao, Yufei Lan, Hui Liu, Yongfa Zhu, Weiru Liu, Jianjun Zhang, Le Jia*. Antioxidant and hepatoprotective activities of polysaccharides from spent mushroom substrates (Laetiporus sulphureus) in acute alcohol-induced mice. Oxidative Medicine and Cellular Longevity. 2017, Article ID 5863523, https://doi.org/10.1155/2017/5863523
6. Zheng Gao, Chen Zhang, Chengye Tian, Zhenzhen Ren, Xinling Song, Xiuxiu Wang, Nuo Xu, Huijuan Jing, Shangshang Li, Weiru Liu, Jianjun Zhang, Le Jia*. Characterization, antioxidation, anti-inflammation and renoprotection effects of selenized mycelia polysaccharides from Oudemansiella radicata.Carbohydrate Polymers. 2018, 181: 1224–1234
7. Chen Zhang, Juan Li, Chunlong Hu, Jing Wang, Jianjun Zhang, Zhenzhen Ren, Xinling Song, Le Jia*. Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice. 2017, Scientific Reports. DOI:10.1038/s41598-017-11457-w.
8. Huijuan Jing, Juan Li, Jianjun Zhang, Wenshuai Wang, Shangshang Li, Zhenzhen Ren, Zheng Gao, Xinling Song, Xiuxiu Wang, Le Jia*. The antioxidative and anti-aging effects of acidic- andalkalic-extractable mycelium polysaccharides by Agrocybe aegerita (Brig.) Sing. 2017, International Journal of Biological Macromolecules. 2018, 106: 1270–1278.
9. Shangshang Li, Hui Liu, Wenshuai Wang, Xiuxiu Wang, Chen Zhang, Jianjun Zhang, Huijuan Jing, Zhenzhen Ren, Zheng Gao, Xinling Song, Le Jia*. Antioxidant and anti-aging effects of acidic-extractable polysaccharides by Agaricus bisporus. 2017, International Journal of Biological Macromolecules. 2018, 106: 1297–1306.
10. Zhenzhen Ren, Juan Li, Xinling Song, Jianjun Zhang, Wenshuai Wang, Xiuxiu Wang, Zheng Gao, Huijuan Jing, Shangshang Li, Le Jia*. The regulation of inflammation and oxidative status against lung injury of residue polysaccharides by Lentinula edodes. 2017, International Journal of Biological Macromolecules. 2018, 106: 185–192.
11. Shangshang Li, Juan Li, Jianjun Zhang, Wenshuai Wang, Xiuxiu Wang, Huijuan Jing, Zhenzhen Ren, Zheng Gao, Xinling Song, Zhiyuan Gong, Le Jia*. The antioxidative, antiaging, and hepatoprotective effects of alkali-extractable polysaccharides by Agaricus bisporus. Evidence-Based Complementary and Alternative Medicine. Volume 2017, Article ID 7298683, 12 pages. https://doi.org/10.1155/2017/7298683.
12. Chen Zhang, Juan Li, Jing Wang, Xinling Song, Jianjun Zhang, Shang Wu, Chunlong Hu, Zhiyuan Gong, Le Jia*. Antihyperlipidaemic and hepatoprotective activities of acidic and enzymatic hydrolysis exopolysaccharides from Pleurotus eryngii SI-04. BMC Complementary and Alternative Medicine. 2017, 17: 403–413.
13. Zhenzhen Ren, Juan Li, Nuo Xu, Jianjun Zhang, Xinling Song, Xiuxiu Wang, Zheng Gao, Huijuan Jing, Shangshang Li, Chen Zhang, Min Liu, Huajie Zhao, Le Jia*. Anti-hyperlipidemic and antioxidant effects of alkali-extractable mycelia polysaccharides by Pleurotus eryngii var. tuolensis. Carbohydrate Polymers. 2017, 175: 282–292.
14. Zheng Gao, Juan Li, Xinling Song, Jianjun Zhang, Xiuxiu Wang, Huijuan Jing, Zhenzhen Ren, Shangshang Li, Chen Zhang, Le Jia*. Antioxidative, anti-inflammation and lung-protective effects of mycelia selenium polysaccharides from Oudemansiella radicata. International Journal of Biological Macromolecules. 2017, 104: 1158–1164.
15. Fengping Jiao, Lu Long, Shanlong Ding, Xiaomeng Xie, Le Jia*, Fengmin Lu. Complete genome sequencing and clinical analysis of intrahepatic hepatitis B virus cccDNA from HCC. Microbial Pathogenesis. 2017, 109: 49–55.
16. Huajie Zhao, Juan Li, Jianjun Zhang, Xiuxiu Wang, Min Liu, Chen Zhang, Le Jia*. Hepatoprotective and in vitro antioxidant effects of native depolymerised-exopolysaccharides derived from Termitomyces albuminosus. Scientific Reports. 2017, DOI:10.1038/s41598-017-04171-0.
17. Huajie Zhao, Juan Li, Jianjun Zhang, Xiuxiu Wang, Long Hao, Le Jia*. Purification, in vitro antioxidant and in vivo anti-aging activities of exopolysaccharides by Agrocybe cylindracea.International Journal of Biological Macromolecules. 2017, 102: 351–357.
18. Min Liu, Xinling Song, Jianjun Zhang, Chen Zhang, Zheng Gao, Shangshang Li, Huijuan Jing, Zhenzhen Ren, Shouxian Wang, Le Jia*. Protective effects on liver, kidney and pancreas of enzymatic- and acidic-hydrolysis of polysaccharides by spent mushroom compost (Hypsizigus marmoreus). Scientific Reports. DOI: 10.1038/srep43212.
19. Fengping Jiao, Xiuxiu Wang, Xinling Song, Huijuan Jing, Shangshang Li, Zhenzhen Ren, Zheng Gao, Jianjun Zhang, Le Jia*. Processing optimization and anti-oxidative activity of enzymatic extractable polysaccharides from Pleurotus djamor. International Journal of Biological Macromolecules. 2017, 98: 469–478.
20. Chen Zhang, Zheng Gao, Chunlong Hu, Jianjun Zhang, Xinyi Sun,Chengbo Rong, Le Jia*. Antioxidant, antibacterial and anti-aging activities of intracellular zinc polysaccharides from Grifola frondosa SH-05. International Journal of Biological Macromolecules. 2017, 95: 778–787.
21. Nuo Xu, Zhenzhen Ren, Jianjun Zhang, Xinling Song, Zheng Gao, Huijuan Jing, Shangshang Li, Shouxian Wang, Le Jia*. Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis. International Journal of Biological Macromolecules. 2017, 95: 204–214.
22. Nuo Xu, Zheng Gao, Jianjun Zhang, Huijuan Jing, Shangshang Li, Zhenzhen Ren, Shouxian Wang, Le Jia*. Hepatoprotection of enzymatic-extractable mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis. Carbohydrate Polymers. 2017, 157: 196–206.
23. Jianjun Zhang, Zheng Gao, Shangshang Li, Shanglong Gao, Zhenzhen Ren, Huijuan Jing, Le Jia*. Purification, characterization, antioxidation, and antiaging properties of exopolysaccharides and endopolysaccharides of the Royal Sun medicinal mushroom, Agaricus brasiliensis. International Journal of Medicinal Mushrooms. 2016, 18(12): 1071–1081.
24. Min Liu, Huijuan Jing, Jianjun Zhang, Gen Che, Meng Zhou, Zheng Gao, Shangshang Li, Zhenzhen Ren, Long Hao, Yu Liu, Le Jia*.Optimization of mycelia selenium polysaccharide extraction from Agrocybe cylindracea SL-02 and assessment of their antioxidant and anti-ageing activities. Plos One. 2016, 11(8): e0160799. doi:10.1371/journal.pone.0160799
25. Huajie Zhao, Shangshang Li, Jianjun Zhang, Gen Che, Meng Zhou, Min Liu, Chen Zhang, Nuo Xu, Lin Lin ,Yu Liu, Le Jia*. The antihyperlipidemic activities of enzymatic and acidic intracellular polysaccharides by Termitomyces albuminosus. Carbohydrate Polymers. 2016, 151: 1227–1234.
26. Lin Lin, Fangyuan Cui, Jianjun Zhang, Xia Gao, Meng Zhou, Nuo Xu, Huajie Zhao, Min Liu, Chen Zhang, Le Jia*. Antioxidative and renoprotective effects of residue polysaccharidesfrom Flammulina velutipes. Carbohydrate Polymers. 2016, 146: 388–395.
27. Jianjun Zhang, Min Liu, Yongheng Yang, Lin Lin, Nuo Xu, Huajie Zhao,Le Jia*. Purification, characterization and hepatoprotective activitiesof mycelia zinc polysaccharides by Pleurotus djamor.Carbohydrate Polymers. 2016, 136: 588–597.
28. Chen Zhang, Shangshang Li, Jianjun Zhang, Chunlong Hu, Gen Che, Meng Zhou, Le Jia*. Antioxidant and hepatoprotective activities of intracellularpolysaccharide from Pleurotus eryngii SI-04. International Journal of Biological Macromolecules. 2016, 91: 568–577.
29. Jianjun Zhang, Xia Gao, Yaogang Pan, Nuo Xu, Le Jia*. Toxicology and immunology of Ganoderma lucidum polysaccharides in Kunming mice and Wistar rats. International Journal of Biological Macromolecules. 2016, 85: 302–310.
30. Jianjun Zhang, Guangyuan Meng, Guoyin Zhai, Yongheng Yang, Huajie Zhao, Le Jia*. Extraction, characterization and antioxidant activity of polysaccharides of spent mushroom compost of Ganoderma lucidum. International Journal of Biological Macromolecules. 2016, 82: 432–439.
31. Min Liu, Guangyuan Meng, Jianjun Zhang, Huajie Zhao, Le Jia*. Antioxidant and hepatoprotective activities of mycelia selenium polysaccharide by Hypsizigus marmoreus SK-02. Biological Trace Element Research. 2016,172: 437–448.
32. Fangyuan Cui, Xia Gao, Jianjun Zhang, Min Liu, Chen Zhang, Nuo Xu, Huajie Zhao, Lin Lin, Meng Zhou, Le Jia*. Protective effects of extracellular and intracellular polysaccharides on hepatotoxicity by Hericium erinaceus SG-02. Current Microbiology. 2016, 73: 379–385.
33. Jianjun Zhang, Guangyuan Meng, Chen Zhang, Lin Lin, Nuo Xu, Min Liu, Fangyuan Cui, Le Jia*. The antioxidative effects of acidic-, alkalic-, and enzymatic-extractable mycelium zinc polysaccharides by Pleurotus djamor on liver and kidney of streptozocin-induced diabetic mice. BMC Complementary and Alternative Medicine. 2015, 15: 440–451.
34. Jianjun Zhang, Nuo Xu, Guoyi Wang, Huajie Zhao, Lin Lin, Mengshi Jia, Le Jia*. In vitro and in vivo antioxidant effects of polysaccharides from Nameko medicinal mushroom, Pholiota nameko SW-01 (Higher Basidiomycetes). International Journal of Medicinal Mushrooms. 2015, 17: 671–680.
35. Liqin Wang, Nuo Xu, Jianjun Zhang, Huajie Zhao, Lin Lin, Shouhua Jia, Le Jia*. Antihyperlipidemic and hepatoprotective activities of residue polysaccharide from Cordyceps militaris SU-12. Carbohydrate Polymers. 2015, 131: 355–362.
36. Liqin Wang, Cuiqin Wang, Xia Gao, Nuo Xu, Lin Lin, Huajie Zhao, Shouhua Jia, Le Jia*. Purification, characterization and anti-aging capacity of mycelia zinc polysaccharide by Lentinus edodes SD-08. BMC Complementary and Alternative Medicine. 2015, 15: 111–122.
37. Lan Zheng, Min Liu, Guoyin Zhai, Zhao Ma, Liqin Wang, Le Jia*. Antioxidant and anti-ageing activities of mycelia zinc polysaccharide from Pholiota nameko SW-03. Journal of the Science of Food and Agriculture. 2015, 95: 3117–3126.
38. Zhao Ma, Chen Zhang, Xia Gao, Fangyuan Cui, Jianjun Zhang, Mengshi Jia, Shouhua Jia, Le Jia*. Enzymatic and acidic degradation effect on intracellular polysaccharide of Flammulina velutipes SF-08. International Journal of Biological Macromolecules. 2015, 73: 236–244.
39. Zhao Ma, Fangyuan Cui, Xia Gao, Jianjun Zhang, Lan Zheng, Le Jia*. Purification, characterization, antioxidant activity and anti-3 aging of exopolysaccharides by Flammulina velutipes SF-06. Antonie van Leeuwenhoek Journal of Microbiology(ISSN: 0003-6072). 2015, 107: 73–82.
40. Jianjun Zhang, Zhao Ma, Lan Zheng, Guoyin Zhai, Liqin Wang, Mengshi Jia, Le Jia*. Purification and antioxidant activities of intracellular zinc polysaccharides from Pleurotus cornucopiae SS-03. Carbohydrate Polymers. 2014, 111: 947–954.
41. Lan Zheng, Guoyin Zhai, Jianjun Zhang, Liqin Wang, Zhao Ma, Mengshi Jia,Le Jia*. Antihyperlipidemic and hepatoprotective activities of mycelia zinc polysaccharide from Pholiota nameko SW-02. International Journal of Biological Macromolecules. 2014, 70: 523–529.
42. Lan Zheng, Long Hao, Hua Ma, Chengye Tian, Tong Li, Xinyi Sun, Mengshi Jia, Le Jia*. Production and in vivo antioxidant activity of Zn, Ge, Se-enriched mycelia by Cordyceps sinensis SU-01. Current Microbiology. 2014, 69: 270–276.
43. Suqian Wu, Shanglong Gao, Honghong Liu, Xinyi Sun, Long Hao, Le Jia*, Lifei Pang, Shouhua Jia, Mengshi Jia. Intracellular polysaccharide and its antioxidant activity by Pleurotus citrinopileatus SM-01. Macromolecular Research. 2013, 21 (6): 660–668.
44. Xinyi Sun, Long Hao, Hua Ma, Tong Li, Lan Zheng, Zhao Ma, Guoyin Zhai, Liqin Wang, Shanglong Gao, Xiaonan Liu, Mengshi Jia, Le Jia*. Extraction and in vitro antioxidant activity of exopolysaccharide by Pleurotus eryngii SI-02. Brazilian Journal of Microbiology. 2013, 44 (4): 1081–1088.
45. Jianjun Zhang, Zhaogang Sun, Yu Tian, Lifei Pang, Mengshi Jia, Honghong Liu, Suqian Wu, Guoyi Wang, Li Wang, Shouhua Jia, Le Jia*. Extraction optimization of exopolysaccharide by Pleurotus cornucopiae SS-02 and its antioxidant activity. African Journal of Biotechnology. 2012, 11(21): 4815–4825.
46. Zhaogang Sun, Yu Tian, Mengshi Jia, Lifei Pang, Peng Deng, Keming Fan, Xiaonan Liu, Shouhua Jia, Le Jia*. Extraction and in vitro antioxidant activity of exopolysaccharide by Pholiota adiposa SX-01. African Journal of Microbiology Research. 2012, 6(8): 1869–1876.
47. Rongshan Lin, Honghong Liu, Suqian Wu, Lifei Pang, Mengshi Jia, Keming Fan, Shouhua Jia, Le Jia*. Production and in vitro antioxidant activity of exopolysaccharide by a mutant, Cordyceps militaris SU5-08. International Journal of Biological Macromolecules. 2012, 51: 153–157.
48. Hui Zou, Guangyuan Meng, Ran Wei, Yawei Zhang, Yilun Chen, Le Jia*. Biochemical Properties of Oxidases by Yali pear. African Journal of Biotechnology. 2012, 11 (53): 11610–11619.
49. Honghong Liu, Liqin Wang, Zhaogang Sun,Lifei Pang, Mengshi Jia, Suqian Wu, Xinyi Sun, Long Hao, Shanglong Gao, Shouhua Jia, Le Jia*. Production and antioxidant activity of intracellular polysaccharide by Hypsizigus marmoreus SK-01. Bioresources. 2012, 7 (4): 5879–5893.
50. Li Wang, Guoyi Wang, Jianjun Zhang, Guquan Zhang,Le Jia*, Xiaonan Liu, Peng Deng, Keming Fan. Extraction optimization and antioxidant activity of intracellular selenium polysaccharide by Cordyceps sinensis SU-02. Carbohydrate Polymers. 2011, 86: 1745–1750.
51. Peng Deng, Guquan Zhang, Bo Zhou, Rongshan Lin, Le Jia*, Keming Fan, Xiaonan Liu, Guoyi Wang, Li Wang, Jianjun Zhang. Extraction and in vitro antioxidant activity of intracellular polysaccharide by Pholiota adiposa SX-02. Journal of Bioscience and Bioengineering. 2011, 111: 50–54.
52. Keming Fan, Guangyuan Meng, Bo Zhou, Peng Deng, Xiaonan Liu, Le Jia*, Guoyi Wang, Li Wang, Jianjun Zhang. Intracellular polysaccharide and its antioxidant activity by Cordyceps militaris SU-08. Journal of Applied Polymer Science. 2011, 120: 1744–1751.
53. Yilun Chen, Jianjun Zhang,Chunmei Li, Zhiqiang Chen, Le Jia*. Extraction, purification and in vitro antioxidant activity of Mopan persimmon polysaccharide. Journal of Applied Polymer Science. 2011, 124: 1751–1756.
54. Fanyun Meng, Bo Zhou, Rongshan Lin, Le Jia*, Xiaonan Liu, Peng Deng, Keming Fan, Guoyi Wang, Li Wang, Jianjun Zhang. Extraction optimization and in vivo antioxidant activities of exopolysaccharide by Morchella esculenta SO-01. Bioresource Technology. 2010, 101: 4564–4569.
55. Fanyun Meng, Xiaonan Liu, Le Jia*, Zhen Song, Peng Deng, Keming Fan. Optimization for the production of exopolysaccharides from Morchella esculenta SO-02 in submerged culture and its antioxidant activities in vitro. Carbohydrate Polymers. 2010, 79: 700–704.
56. Xiaonan Liu, Bo Zhou, Rongshan Lin, Le Jia*, Peng Deng, Keming Fan, Guoyi Wang, Li Wang, Jianjun Zhang. Extraction and antioxidant activities of intracellular polysaccharide from Pleurotus sp. mycelium. International Journal of Biological Macromolecules. 2010, 47: 116–119.
57. Bo Zhou, Le Jia*,Fanyun Meng, Zhen Song, Xiaonan Liu, Peng Deng, Keming Fan. Statistical optimization of cultivation conditions for exopolysacchride production and mycelia growth by Stropharia rugosoannulata. Annals of Microbiology. 2010, 60: 89–96.
58. Fanyun Meng, Xiaonan Liu, Le Jia*, Zhen Song, Peng Deng, Keming Fan. Culture optimization and amino acid composition of Cr-enriched mycelia by Pleurotus cornucopiae SD-01. Food Technology and Biotechnology.2010, 48: 107–113.
59. Zhen Song, Le Jia*, Feng Xu, Fanyun Meng, Peng Deng, Keming Fan, Xiaonan Liu. Characteristics of Se-enriched mycelia by Stropharia rugoso-annulata and its antioxidant activities in vivo.Biological Trace Element Research. 2009, 131: 81–89.
60. Le Jia*, Shunzhen Hu, Mei Xu. Optimization of submerged culture conditions for the production of mycelial biomass and exopolysaccharide by Pleurotus nebrodensis. Annals of Microbiology. 2007, 7 (3): 389–393.
61.Le Jia, Jie Liu, Bo Zhou, Feng Xu, Kexue Yu, Fujiang Wen. The effect of Zn on the Zn accumulation and biosynthesis of amino acid in mycelia of Cordyceps sinensis. Biological Trace Element Research. 2006, 113: 45–51.
